|
Esophageal Achalasia
|
0.520 |
SusceptibilityMutation
|
disease |
ORPHANET |
In addition, two amino acid substitutions in the extracellular domain of HLA-DQα1 at position 41 (lysine encoded by HLA-DQA1*01:03; P=5.60×10(-10)) and of HLA-DQβ1 at position 45 (glutamic acid encoded by HLA-DQB1*03:01 and HLA-DQB1*03:04; P=1.20×10(-9)) independently confer achalasia risk.
|
24997987 |
2014 |
|
Idiopathic achalasia of esophagus
|
0.300 |
SusceptibilityMutation
|
disease |
ORPHANET |
Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia.
|
24997987 |
2014 |
|
Celiac Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Here, we demonstrated that HLA DQA1*05 and DQB1*02 gene expression is much higher than expression of non-CD-associated genes.
|
27083396 |
2016 |
|
Celiac Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
CD is a gluten-sensitive enteropathy, strongly associated with expression of the DQA1*0501, DQB1*0201 genotype.
|
7558926 |
1995 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Differential expression of insulin-dependent diabetes mellitus-associated HLA-DQA1 alleles in vivo.
|
9209509 |
1997 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Significantly higher mean basal levels of 2'-5' oligoadenylate synthetase activity were associated with HLA-DQA 4.6 phenotype (determined using the restriction enzyme Taq 1 and a DQA probe) and HLA-DR3 (determined serologically), whereas significantly lower mean levels of enzyme activity were associated with HLA-DQA 5.5 and HLA-DR7, in both IDDM and control subjects.
|
2687162 |
1989 |
|
Asthma
|
0.490 |
AlteredExpression
|
disease |
BEFREE |
The cluster analysis of these DEGs showed that 4 genes, including human leukocyte antigen (HLA-DQA1), HLA-DRB4, integrin 3 (ITGB3) and killer cell lectin-like receptor subfamily F member 1 (KLRF1) were all significantly expressed in 3 groups, which were significantly enriched in asthma, T1D and intestinal immune network for IgA production pathway.
|
24838153 |
2014 |
|
Myasthenia Gravis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
These date suggest that LG type of MG may present a particular subset of childhood-onset MG, which is associated with the specific HLA subtypes DRB1*1302/DQA1*0102/DQB1*0604 and DRB1*0901/DQA1*0301/DQB1*0303.
|
15003812 |
2004 |
|
Liver carcinoma
|
0.150 |
AlteredExpression
|
disease |
BEFREE |
In addition, the decreased mRNA expression of STAT4, HLA-DQA1, and HLA-DQB1 in HCC tissue might provide a clue to understanding their role in the progression to HCC.
|
25913043 |
2015 |
|
Liver carcinoma
|
0.150 |
AlteredExpression
|
disease |
LHGDN |
Four of these genes (HLA-DRA, HLA-DRB1, HLA-DG and HLA-DQA), encoding MHC class II antigens, were coordinately downregulated in HCCs with early IHR compared to levels in HCCs with nonrecurrence.
|
15688398 |
2005 |
|
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The DQA1*0501, DQB1*0301, and DRB1*0401 alleles, and the DQA1*0301-DQB1*0301, DQA1*0501-DQB1*0301, and DRB1*1101-DQB1*0301 haplotypes seem to be associated with low hepatitis activity; whereas DQB1*0201 allele is closely correlated with the progression of liver injury in chronic HCV infection.
|
18028350 |
2008 |
|
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The haplotype DRB1*0803-DQB1*0601 significantly increased (RR=2.5, P<0.02) while the DQA1*0501-DQB1*0201 significantly decreased (RR=0.2, P<0.03) in chronic HCV carriers compared with normal controls.
|
16343061 |
2005 |
|
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HLA-DQA1-positive cells in the liver sinusoid were positive for CD68 (macrophages or Kupffer cells); those in the lymphocytic infiltrates were positive for CD20 (B cells) or CD3 (T cells). mRNA levels of antigen-presenting cell (APC) markers such as CD68 and CD11c were significantly upregulated in the HCV-high group and were correlated with HLA-DQA mRNA levels.
|
29248968 |
2018 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Patients with family history negative or with tumor sizes >4 cm were associated with higher HLA-DQA1 expression levels.
|
30813145 |
2019 |
|
Arthritis
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We have generated transgenic (tg) mice expressing HLA-DQ8alphabeta (DQA1*0301/DQB*0302) or HLA-DQ6alphabeta (DQA1*0103/DQB1*0601) molecules lacking endogenous murine class II expression (A beta0) to investigate the ability of these HLA class II to present type II collagen (CII) and induce collagen-induced arthritis.
|
9794442 |
1998 |
|
Hepatitis B
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Two HLA class II haplotypes, HLA-[DQB1*0602; DQA1*0102; DR15] and HLA-[DQB1*0603; DQA1*0103; DRB1*1301] were found to be less common in 52 nonresponders compared with 68 responders, P<0.025 and P<0.05 respectively, after vaccination with hepatitis B surface antigen (HBsAg).
|
9820601 |
1998 |
|
Gastritis, Atrophic
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The phenotypic frequencies of DRB1*1101 and DQA1*0505 were significantly higher in the CAG group compared to those in the CSG group.
|
19906105 |
2009 |
|
Dermatomyositis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Gene expression profiling in DQA1*0501+ children with untreated dermatomyositis: a novel model of pathogenesis.
|
11937576 |
2002 |
|
Adult type dermatomyositis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Gene expression profiling in DQA1*0501+ children with untreated dermatomyositis: a novel model of pathogenesis.
|
11937576 |
2002 |
|
Squamous cell carcinoma of esophagus
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
HLA-DQA1 mRNA and protein expression were significantly higher in ESCC tissues compared to the matched normal tissues.
|
30813145 |
2019 |
|
Hepatitis C, Chronic
|
0.020 |
AlteredExpression
|
disease |
LHGDN |
A total of 145 patients with chronic hepatitis C virus (HCV) infection (36 patients with persistently normal ALT values; 109 patients with elevated ALT levels) and 160 uninfected healthy controls were examined for HLA-DQA1, DQB1, and DRB1 molecules by using polymerase chain reaction-sequencing based typing (PCR-SBT).
|
18028350 |
2008 |
|
Oligoarticular Juvenile Idiopathic Arthritis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Intra-articular upregulation of HLA-DQA1 was predominantly observed for the OA-JIA associated allele HLA-DQA1*04.
|
19811310 |
2009 |
|
Craniosynostosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Patients with CRS showed significant increases in the expression of ctla4 and jak1 in sinonasal tissue and blood (p < 0.05), whereas the gene expression of hla-dqa1, hla-dqb1, and dusp4 was significantly decreased in patients with CRS compared to controls (p < 0.05).
|
30657646 |
2019 |
|
Esophageal Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We analyzed the expression profiles of HLA-DQA1 in esophageal cancer (EC) samples in the TCGA database and validated HLA-DQA1 expression by immunohistochemistry, western blotting, and quantitative reverse-transcription polymerase chain reaction in matched EC and normal tissues, respectively.
|
30813145 |
2019 |
|
Optic Neuritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The frequencies of HLA-DQA-1B (55% in ON + CDMS, 58% in ON) and HLA-DQB-1B (49% in ON + CDMS, 59% in ON) were significantly increased compared with control subjects (41%, HLA-DQA-1B; 37%, HLA-DQB-1B).
|
9006417 |
1997 |